Back to projects
Enzyme Engineering for the Biosynthesis of Therapeutics
Exploring, characterising and evolving enzymes involved in the biosynthesis of therapeutically relevant molecules, with emphasis on selectivity, substrate scope and biocatalytic potential.
Enzyme discoveryBiocatalysisSubstrate scopeBiosynthesis
Overview
A method-focused case study in discovering, characterising and engineering enzymes that build therapeutically relevant molecules, combining biochemical and computational interpretation.
Scientific question
How can enzymes be discovered and engineered to enable selective, sustainable routes to complex therapeutic molecules?
Why it matters
Enzymes can enable selective and sustainable routes to complex therapeutic molecules, reducing reliance on harsh reagents and improving stereo- and regioselectivity.
Approach
Combine biochemical characterisation, enzyme assays, substrate-scope analysis, structural/computational interpretation and machine-learning-guided thinking.
Relevance to biotech/pharma
Biocatalysis is increasingly central to green chemistry and pharmaceutical manufacturing, supporting selective synthesis, scalable processes and novel therapeutic chemistries.
Selected outputs / publications
Selected publications relate to enzymatic cascades, beta-lactone biosynthesis and enzyme-mediated amide bond assembly. See the Publications page for the full list.